Transdifferentiation is the name used to describe the conversion of one differentiated cell type to another. During development, the liver and pancreas arise from the same region of the endoderm and cells from the two organs can transdifferentiate in the adult under different experimental procedures. We have produced two in vitro models for the transdifferentiation of pancreatic cells to hepatocytes. The first utilizes a pancreatic exocrine cell line AR42J-B13 and the second comprises cultures of mouse embryonic pancreas. We have analysed the pancreatic hepatocytes and they express a range of liver markers including albumin, transferrin and transthyretin. We also present evidence for (i) the molecular mechanism which regulates the conversion between pancreas and liver and (ii) the cellular basis of the switch in phenotype.
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Conference Article|
April 01 2002
Conversion of pancreatic cells to hepatocytes
David Tosh;
David Tosh
1
1Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, U.K.
1To whom correspondence should be addressed (e-mail d.tosh@bath.ac.uk).
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Chia-Ning Shen;
Chia-Ning Shen
1Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, U.K.
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Jonathan M. W. Slack
Jonathan M. W. Slack
1Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, U.K.
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Publisher: Portland Press Ltd
Received:
November 30 2001
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (2): 51–54.
Article history
Received:
November 30 2001
Citation
David Tosh, Chia-Ning Shen, Jonathan M. W. Slack; Conversion of pancreatic cells to hepatocytes. Biochem Soc Trans 1 April 2002; 30 (2): 51–54. doi: https://doi.org/10.1042/bst0300051
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