Short-term regulation of insulin gene transcription is still a matter of debate. However, an increasing body of evidence shows that insulin gene transcription is affected by signals, such as incretins, glucose metabolites, intracellular Ca2+, and by insulin secreted from pancreatic β-cells, all supporting the concept of an immediate response resulting in insulin gene transcription following food-uptake. The present review aims to summarize the current view on the mechanisms underlying the up-regulation of insulin gene transcription in response to glucose, the major nutrient factor in insulin secretion and biosynthesis.
Keywords:
CaM kinase, Ca2+/calmodulin-dependent protein kinase,
IGF, insulin-like growth factor,
PDKI, phos-phoinositide-dependent kinase I,
PDX-1, pancreatic duodenal homeobox-containing transcription factor I,
PI 3 kinase, phos-phoinositide 3-kinase,
p70s6k, p70 s6 kinase,
SAPK2a, stress-activated protein kinase 2a,
immediate early gene,
insulin receptor,
phosphoinositide 3-kinase
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© 2002 Biochemical Society
2002
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