AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic β-cells.
Keywords:
gene expression,
glucose,
pancreatic β-cell,
ACC, acetyl-CoA carboxylase,
Ad.αIDN, adenovirus encoding a dominant negative form of the α I-subunit of AMPK,
AICAR, 5-aminoimidazole-4-carboxamide riboside,
AMPK, AMP-activated protein kinase,
FAS, fatty acid synthase,
GK, glucokinase,
GLUT, glucose transporter
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© 2002 Biochemical Society
2002
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