Src was the first oncogene to be discovered, and the first protein tyrosine kinase. The study of how Src transforms cells has been a rich field that has lead to insights into the control of the cell cycle, the organization of the cytoskeleton, and growth factor-independent growth. Yet we still do not fully understand exactly what Src does. In normal cells, Src has been implicated in the control of cell division, the production of autocrine growth factors, the cell's survival response, as well as in cell motility. My laboratory has focused on the involvement of Src and related kinases in the response of cells to mitogenic growth factors. We have shown that the activity of Src kinases is necessary for cells to enter the cell cycle when treated with mitogens such as platelet-derived growth factor. Src activity initiates a signal transduction cascade, involving the adaptor protein She, which culminates in the transcriptional activation of the transcription factor Myc. Furthermore, we have also shown that this requirement for Src is abrogated in cells lacking the tumour suppressor p53, suggesting that another of Src's functions in normal cells is to suppress the actions of p53.
Skip Nav Destination
Article navigation
April 2002
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkAdvertising
Conference Article|
April 01 2002
Role of Src in Signal Transduction Pathways
S. A. Courtneidge
S. A. Courtneidge
1
1Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, U.S.A.
1e-mail sara.courtneidge@vai.org
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
December 19 2001
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (2): 11–17.
Article history
Received:
December 19 2001
Citation
S. A. Courtneidge; Role of Src in Signal Transduction Pathways. Biochem Soc Trans 1 April 2002; 30 (2): 11–17. doi: https://doi.org/10.1042/bst0300011
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.