Translesion replication is a mechanism that employs specialized DNA polymerases for promoting continued nascent strand extension at forks blocked by the presence of unrepaired DNA damage. In Saccharomyces cerevisiae at least, this process contributes only modestly to the ability of cells to tolerate DNA damage, but is a major source of DNA-damage-induced substitutions and frameshifts, and of spontaneous mutations. Translesion replication past many types of DNA damage in yeast depends on the activities of DNA polymerase ζ (pol ζ) and Revlp. Pol ζ is found in most, but not all, eukaryotes investigated, whereas Revlp appears to be universal. Genes encoding these enzymes are found in humans, and appear to perform functions similar to those in yeast.
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Conference Article|
May 01 2001
Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase ζ and Rev I protein
C. W. Lawrence;
C. W. Lawrence
1
*Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, U.S.A.
1To whom correspondence should be addressed (e-mail christopher-lawrence@urmc.rochester.edu)
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V. M. Maher
V. M. Maher
†Carcinogenesis Laboratory, Department of Microbiology and Department of Biochemistry, Michigan State University, East Lansing, MI 48824, U.S.A.
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Publisher: Portland Press Ltd
Received:
December 21 2000
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2001 Biochemical Society
2001
Biochem Soc Trans (2001) 29 (2): 187–191.
Article history
Received:
December 21 2000
Citation
C. W. Lawrence, V. M. Maher; Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase ζ and Rev I protein. Biochem Soc Trans 1 May 2001; 29 (2): 187–191. doi: https://doi.org/10.1042/bst0290187
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