Over recent years our understanding of the functions of the heparan sulphate (HS) family of complex polysaccharides has shifted dramatically. Once seen as simply structural scaffolding in the extracellular matrix, they are now viewed as critical players in the regulatory network of cells. They are strategically located at the cell surface and in the extracellular matrix, and there has been an increasing realization that specific sequences in the HS chains are designed for selective interactions with many proteins. Functionally, these interactions result in regulation of the protein activities. It is becoming clear that HS functions as a new class of multifunctional cell regulator. There is also growing evidence that cells can dynamically alter the structure of HS sequences that they express. Here we review recent developments and describe evidence for regulated changes in the synthesis and structure of HS chains expressed during early mouse brain development. The data suggest a new concept in which dynamic changes in biosynthesis of different HS sequences create distinct cellular HS repertoires, the heparanome [1]. Their expression, in specific spatio-temporal patterns, is likely to endow organisms with novel regulatory mechanisms for controlling the activity of specific HS-binding proteins.
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Conference Article|
May 01 2001
Dynamic biosynthesis of heparan sulphate sequences in developing mouse brain: a potential regulatory mechanism during development
S. Guimond;
S. Guimond
*School of Biosciences, University of Birmingham, Edgbaston, Birmingham BI5 2TT, U.K.
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K. Turner;
K. Turner
†Department of Anatomy and Cell Biology, University of Melbourne, 3010, Victoria, Australia
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M. Kita;
M. Kita
†Department of Anatomy and Cell Biology, University of Melbourne, 3010, Victoria, Australia
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M. Ford-Perriss;
M. Ford-Perriss
†Department of Anatomy and Cell Biology, University of Melbourne, 3010, Victoria, Australia
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J. Turnbull
J. Turnbull
1
*School of Biosciences, University of Birmingham, Edgbaston, Birmingham BI5 2TT, U.K.
1To whom correspondence should be addressed (e-mail j.e.tumbull@bham.ac.uk)
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Publisher: Portland Press Ltd
Received:
December 21 2000
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2001 Biochemical Society
2001
Biochem Soc Trans (2001) 29 (2): 177–181.
Article history
Received:
December 21 2000
Citation
S. Guimond, K. Turner, M. Kita, M. Ford-Perriss, J. Turnbull; Dynamic biosynthesis of heparan sulphate sequences in developing mouse brain: a potential regulatory mechanism during development. Biochem Soc Trans 1 May 2001; 29 (2): 177–181. doi: https://doi.org/10.1042/bst0290177
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