In mouse uterine luminal epithelium (LE) several terminal carbohydrate structures are regulated by ovarian steroids and show stage-specific expression during early pregnancy. We have demonstrated that expression of H-type-1 antigen (Fucα1-2Galβ1-3GlcNAcβ1-) is regulated by oestrogenic stimulation of α-2fucosyltransferase (fut1) mRNA levels in LE. H-type-1 expression is high after ovulation but becomes negligible after implantation. In contrast, NeuNAcα2-3Galβ1-, and specifically sialyl Le-x (NeuAcα2,3Galβ1,4-[Fucα1-3]GlcNAcβ1-), is stimulated by progesterone. It is not expressed on LE after ovulation but is expressed maximally on apical LE at the time of and after implantation. However, mRNA levels for 4 out of 5 known Gal/GalNAc α2-3sialyltransferases appear not to change in LE during early pregnancy, suggesting an alternative level of control.
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Conference Article|
May 01 2001
Glycosylation changes during differentiation of the murine uterine epithelium
S. J. Kimber;
S. J. Kimber
1
1School of Biological Sciences, University of Manchester, 3.239 Stopford Building, Oxford Rd., Manchester M13 9PT, U.K.
1To whom correspondence should be addressed (skimber@fsl.scg.man.ac.uk)
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R. E. Stones;
R. E. Stones
1School of Biological Sciences, University of Manchester, 3.239 Stopford Building, Oxford Rd., Manchester M13 9PT, U.K.
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Publisher: Portland Press Ltd
Received:
November 20 2000
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2001 Biochemical Society
2001
Biochem Soc Trans (2001) 29 (2): 156–162.
Article history
Received:
November 20 2000
Citation
S. J. Kimber, R. E. Stones, S. S. Sidhu; Glycosylation changes during differentiation of the murine uterine epithelium. Biochem Soc Trans 1 May 2001; 29 (2): 156–162. doi: https://doi.org/10.1042/bst0290156
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