Historically, two strategies have been used to dissect the insulin signal transduction pathway. One was to start at the insulin receptor and work down the signal transduction pathway from the plasma membrane. The other was to select a physiological action of insulin, namely the mechanism by which insulin stimulates glycogen synthesis, and then work backwards towards the receptor. The hope was that eventually the groups working down from the top of the insulin signalling pathway would meet up with those working upwards from the bottom of the pathway. This has now happened, and in this lecture I will describe the recent advances that have linked the research from both ends of the insulin signal transduction pathway. I will also discuss how these findings have enabled pharmaceutical companies to embark on novel programmes to develop improved therapies for the treatment of diabetes in the future.
Skip Nav Destination
Article navigation
May 2001
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkAdvertising
Conference Article|
May 01 2001
Discovery of PDKI, One of the Missing Links in Insulin Signal Transduction
D. R. Alessi
D. R. Alessi
1
1MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
1e-mail: d.r.alessi@dundee.ac.uk
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
January 05 2001
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2001 Biochemical Society
2001
Biochem Soc Trans (2001) 29 (2): 1–14.
Article history
Received:
January 05 2001
Citation
D. R. Alessi; Discovery of PDKI, One of the Missing Links in Insulin Signal Transduction. Biochem Soc Trans 1 May 2001; 29 (2): 1–14. doi: https://doi.org/10.1042/bst0290001
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.