The major route for the synthesis of triacylglycerol (TAG) in yeast as well as in all TAG-accumulating organisms has been suggested to occur via the acylation of diacylglycerol (DAG) by acyl-CoA: diacylglycerol acyltransferase (DAGAT). Genes encoding DAGAT have been identified in both plant and animal tissues. These genes show strong sequence similarities to genes encoding acyl-CoA: cholesterol acyltransferase (ACAT). So far no Saccharomyces cerevisiae DAGAT gene has been published; however, two ACAT-like genes, ARE1 and ARE2, are present in the yeast genome. Both these genes have been suggested to be involved in the synthesis of sterol esters. We have now shown that the ARE1 gene in yeast also is involved in the synthesis of TAG, whereas the ARE2 gene is more specifically involved in the synthesis of sterol esters.
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Conference Article|
December 01 2000
An acyl-CoA:cholesterol acyltransferase (ACAT)-related gene is involved in the accumulation of triacylglycerols in Sacchoromyces cerevisiae
L. Sandager;
L. Sandager
1
*Department of Plant Breeding Research, Swedish University of Agricultural Sciences, SE-268 31 Svalöv, Sweden
1To whom correspondence should be addressed (e-mail line@sandager.com)
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A. Dahlqvist;
A. Dahlqvist
†Scandinavian Biotechnology Research AB, SE-268 31 Svalöv, Sweden
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A. Banaś;
A. Banaś
†Scandinavian Biotechnology Research AB, SE-268 31 Svalöv, Sweden
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U. Ståhl;
U. Ståhl
‡Scandinavian Biotechnology Research AB, SLU, Genetic Center, Box 7080, SE-270 07 Uppsala, Sweden
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M. Lenman;
M. Lenman
†Scandinavian Biotechnology Research AB, SE-268 31 Svalöv, Sweden
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M. Gustavsson;
M. Gustavsson
*Department of Plant Breeding Research, Swedish University of Agricultural Sciences, SE-268 31 Svalöv, Sweden
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S. Stymne
S. Stymne
*Department of Plant Breeding Research, Swedish University of Agricultural Sciences, SE-268 31 Svalöv, Sweden
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Publisher: Portland Press Ltd
Received:
June 26 2000
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2000 Biochemical Society
2000
Biochem Soc Trans (2000) 28 (6): 700–702.
Article history
Received:
June 26 2000
Citation
L. Sandager, A. Dahlqvist, A. Banaś, U. Ståhl, M. Lenman, M. Gustavsson, S. Stymne; An acyl-CoA:cholesterol acyltransferase (ACAT)-related gene is involved in the accumulation of triacylglycerols in Sacchoromyces cerevisiae. Biochem Soc Trans 1 December 2000; 28 (6): 700–702. doi: https://doi.org/10.1042/bst0280700
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