The gene for enkephalin is expressed only in specific subsets of neurons in the mammalian central nervous system (CNS), whereas the large majority of neurons do not express the gene. This restricted expression is the result of a developmental process during which some of the multi-potent neural progenitors express the gene for enkephalin and thereby become enkephalinergic neurons. The regulation of this process is not well understood. We have used a novel approach to identify DNA-protein interactions that regulate the developmental expression of the gene for enkephalin. We have identified four novel DNA regulatory sites and their binding proteins that are expressed in the developing mammalian CNS. These protein-DNA interactions regulate DNA and nuclear structures through DNA bending, DNA sliding, chromatin remodelling and far-distant DNA interactions. The concerted and coordinated interactions of these four DNA elements and their binding proteins contribute to the guiding of multipotent neural progenitors into enkephalinergic neurons. The provided examples suggest an important role for architectural transcriptional regulation during CNS development.
Skip Nav Destination
Article navigation
August 2000
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkAdvertising
Conference Article|
August 01 2000
Complexity of transcriptional control in neuropeptide gene expression; enkephalin gene regulation during neurodevelopment
D. v. Agoston;
D. v. Agoston
1
1Department of Anatomy, Cell Biology and Program in Neuroscience, School of Medicine, USU, Bethesda, MD 20814, U.S.A.
1To whom correspondence should be addressed (e-mail denes@codon.nih.gov)
Search for other works by this author on:
A. Dobi
A. Dobi
1Department of Anatomy, Cell Biology and Program in Neuroscience, School of Medicine, USU, Bethesda, MD 20814, U.S.A.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
April 13 2000
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2000 Biochemical Society
2000
Biochem Soc Trans (2000) 28 (4): 446–451.
Article history
Received:
April 13 2000
Citation
D. v. Agoston, A. Dobi; Complexity of transcriptional control in neuropeptide gene expression; enkephalin gene regulation during neurodevelopment. Biochem Soc Trans 1 August 2000; 28 (4): 446–451. doi: https://doi.org/10.1042/bst0280446
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.