Three different approaches to constructing bio-sensing units based on double-stranded (ds) DNA molecules, capable of detecting various biologically active compounds, are considered. The first approach is based on the abnormal optical activity of the liquid-crystalline dispersion formed from ds DNA molecules, modified by relevant physical factors or treated with biologically active compounds. The second one is based on the abnormal optical activity of the liquid-crystalline dispersions formed first from the ds DNA and then treated with coloured biologically active compounds. The third one is based on the abnormal optical activity, specific to particles of the liquid-crystalline dispersions, where the neighbouring DNA molecules are crosslinked by artifical polymeric bridges. These approaches permit the detection of biologically relevant compounds of various origins.
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Conference Article|
February 01 2000
Double-stranded DNA liquid-crystalline dispersions as biosensing units
Y. M. Yevdokimov
Y. M. Yevdokimov
1Engelhandt Institute of Molecular Biology of the Russian Academy of Sciences, 117984 Moscow, Vavilova str. 32, Russia
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Publisher: Portland Press Ltd
Received:
July 20 1999
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2000 Biochemical Society
2000
Biochem Soc Trans (2000) 28 (2): 77–81.
Article history
Received:
July 20 1999
Citation
Y. M. Yevdokimov; Double-stranded DNA liquid-crystalline dispersions as biosensing units. Biochem Soc Trans 1 February 2000; 28 (2): 77–81. doi: https://doi.org/10.1042/bst0280077
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