HLA-G is a non-classical class I molecule specifically expressed in the placenta, suggesting that it might have a physiological function at the materno-foetal interface. The structural characteristics of HLA-G, the placental pattern of expression and the functional properties of this class Ib glycoprotein in vitro are described and evaluated in the context of pregnancy. The possible anti-viral function of HLA-G, its modulatory role of natural killer cell activity and its likely nonimmunological functions are discussed.

Keywords:
NK, natural killer, cytotoxic T lymphocytes, HLA-G, natural killer cells, trophoblast
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© 2000 Biochemical Society
2000
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