For nearly two decades now, the RGD (Arg-Gly-Asp)-binding αvβ3-integrin has been a focus of anti-angiogenic drug design. These inhibitors are well-tolerated, but have shown only limited success in patients. Over the years, studies in β3-integrin-knockout mice have shed some light on possible explanations for disappointing clinical outcomes. However, studying angiogenesis in β3-integrin-knockout mice is a blunt tool to investigate β3-integrin's role in pathological angiogenesis. Since establishing our laboratory at University of East Anglia (UEA), we have adopted more refined models of genetically manipulating the expression of the β3-integrin subunit. The present review will highlight some of our findings from these models and describe how data from them have forced us to rethink how targeting αvβ3-integrin expression affects tumour angiogenesis and cancer progression. Revisiting the fundamental biology behind how this integrin regulates tumour growth and angiogenesis, we believe, is the key not only to understanding how angiogenesis is normally co-ordinated, but also in success with drugs directed against it.
Skip Nav Destination
Article navigation
December 2014
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 17 2014
Redefining the role(s) of endothelial αvβ3-integrin in angiogenesis
Samuel J. Atkinson;
Samuel J. Atkinson
1
*School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Search for other works by this author on:
Tim S. Ellison;
Tim S. Ellison
1
*School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Search for other works by this author on:
Veronica Steri;
Veronica Steri
1
*School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Search for other works by this author on:
Emma Gould;
Emma Gould
†School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Search for other works by this author on:
Stephen D. Robinson
Stephen D. Robinson
2
*School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
2To whom correspondence should be addressed (emailstephen.robinson@uea.ac.uk).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 30 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1590–1595.
Article history
Received:
July 30 2014
Citation
Samuel J. Atkinson, Tim S. Ellison, Veronica Steri, Emma Gould, Stephen D. Robinson; Redefining the role(s) of endothelial αvβ3-integrin in angiogenesis. Biochem Soc Trans 1 December 2014; 42 (6): 1590–1595. doi: https://doi.org/10.1042/BST20140206
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.