Adult neurogenesis is a multistage process during which newborn neurons are generated through the activation and proliferation of neural stem cells (NSCs) and integrated into existing neural networks. Impaired adult neurogenesis has been observed in various neurological and psychiatric disorders, suggesting its critical role in cognitive function, brain homeostasis, and neural repair. Over the past decades, mounting evidence has identified a strong association between metabolic status and adult neurogenesis. Here, we aim to summarize how amino acids and their neuroactive metabolites affect adult neurogenesis. Furthermore, we discuss the causal link between amino acid metabolism, adult neurogenesis, and neurological diseases. Finally, we propose that systematic elucidation of how amino acid metabolism regulates adult neurogenesis has profound implications not only for understanding the biological underpinnings of brain development and neurological diseases, but also for providing potential therapeutic strategies to intervene in disease progression.
Macrophages are innate immune cells responsible for a variety of tissue-specific homeostatic functions and responding to infiltrating pathogens. A lot of what we know about macrophages comes from studies on unphysiological 2D plastic dishes, however new insights into macrophage biology are emerging thanks to 3D cell culture technology (see the review in this issue by Cutter et al., pages 387–401). Depicted here is a macrophage suspended within a neon 3D dimension. Image provided by Katrina Binger.
The impact of amino acid metabolism on adult neurogenesis
Ye Guo, Xing Luo, Weixiang Guo; The impact of amino acid metabolism on adult neurogenesis. Biochem Soc Trans 27 February 2023; 51 (1): 233–244. doi: https://doi.org/10.1042/BST20220762
Download citation file:
Sign in to your personal account
Captcha Validation Error. Please try again.