How organisms learn and encode memory is an outstanding question in neuroscience research. Specifically, how memories are acquired and consolidated at the level of molecular and gene pathways remains unclear. In addition, memory is disrupted in a wide variety of neurological disorders; therefore, discovering molecular regulators of memory may reveal therapeutic targets for these disorders. C. elegans are an excellent model to uncover molecular and genetic regulators of memory. Indeed, the nematode's invariant neuronal lineage, fully mapped genome, and conserved associative behaviors have allowed the development of a breadth of genetic and genomic tools to examine learning and memory. In this mini-review, we discuss novel and exciting genetic and genomic techniques used to examine molecular and genetic underpinnings of memory from the level of the whole-worm to tissue-specific and cell-type specific approaches with high spatiotemporal resolution.
Macrophages are innate immune cells responsible for a variety of tissue-specific homeostatic functions and responding to infiltrating pathogens. A lot of what we know about macrophages comes from studies on unphysiological 2D plastic dishes, however new insights into macrophage biology are emerging thanks to 3D cell culture technology (see the review in this issue by Cutter et al., pages 387–401). Depicted here is a macrophage suspended within a neon 3D dimension. Image provided by Katrina Binger.
Uncovering novel regulators of memory using C. elegans genetic and genomic analysis
Katie L. Brandel-Ankrapp, Rachel N. Arey; Uncovering novel regulators of memory using C. elegans genetic and genomic analysis. Biochem Soc Trans 27 February 2023; 51 (1): 161–171. doi: https://doi.org/10.1042/BST20220455
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