Trigeminal neuralgia (TN) is one of the most common neuropathic pain disorders and is often combined with other comorbidities if managed inadequately. However, the present understanding of its pathogenesis at the molecular level remains lacking. Long noncoding RNAs (lncRNAs) play crucial roles in neuropathic pain, and many studies have reported that specific lncRNAs are related to TN. This review summarizes the current understanding of lncRNAs in the pathogenesis, diagnosis, and treatment of TN. Recent studies have shown that the lncRNAs uc.48+, Gm14461, MRAK009713 and NONRATT021972 are potential candidate loci for the diagnosis and treatment of TN. The current diagnostic system could be enhanced and improved by a workflow for selecting transcriptomic biomarkers and the development of lncRNA-based molecular diagnostic systems for TN. The discovery of lncRNAs potentially impacts drug selection for TN; however, the current supporting evidence is limited to preclinical studies. Additional studies are needed to further test the diagnostic and therapeutic value of lncRNAs in TN.
The flower represents the Drosophila testis niche with the hub cells at the center. Each petal of the flower represents Germline stem cells (GSCs) with a large and a smaller purple circle representing centromere; green rays representing stronger centromeres preferentially attach to the niche. Red and green caterpillars represent sister chromatids in prometaphase with separable old and new H3 in GSCs. Further, large butterflies closer to the flower represent prometaphase GSCs with a red wing vs a green wing representing non-overlapping old and new H3. Small orange butterflies away from the flower represent prophase gonialblast cells with overlapping old and new H3 signals. The background is from coiled sperm from the fly testis. Cover art generated by Professor Tim Phelps.
Emerging roles of lncRNAs in the pathogenesis, diagnosis, and treatment of trigeminal neuralgia
Tianyi Wang, Liu Liu, Dongzhe Song, Dingming Huang; Emerging roles of lncRNAs in the pathogenesis, diagnosis, and treatment of trigeminal neuralgia. Biochem Soc Trans 29 April 2022; 50 (2): 1013–1023. doi: https://doi.org/10.1042/BST20220070
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