Myosins, a class of actin-based motor proteins existing in almost any organism, are originally considered only involved in driving muscle contraction, reshaping actin cytoskeleton, and anchoring or transporting cargoes, including protein complexes, organelles, vesicles. However, accumulating evidence reveals that myosins also play vital roles in viral infection, depending on viral species and infection stages. This review systemically summarizes the described various myosins, the performed functions, and the involved mechanisms or molecular pathways during viral infection. Meanwhile, the existing issues are also discussed. Additionally, the important technologies or agents, including siRNA, gene editing, and myosin inhibitors, would facilitate dissecting the actions and mechanisms for described and undescribed myosins, which could be adopted to prevent or control viral infection are also characterized.
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February 2022
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The highly conserved enzyme IMPDH plays an essential role in purine biosynthesis and is tightly regulated by many different mechanisms. Depicted here are cryo-EM structures of the large retinal splice variant of IMPDH1 in different filament assembly conformations overlaid on a cryo-EM micrograph of IMPDH1 filaments. Cover artwork created by Jesse Hansen.
Review Article|
February 25 2022
Understanding the key functions of Myosins in viral infection
Jiayi He;
Jiayi He
*
1Lab of Animal Disease Prevention & Control and Animal Model, Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University (HUNAU), Changsha, Hunan 410128 China
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Yixing Qiu;
Yixing Qiu
*
2TCM and Ethnomedicine Innovation & Development International Laboratory, Academician Atta-ur-Rahman Belt and Road Traditional Medicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, PR China
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Lei Tan;
Lei Tan
*
1Lab of Animal Disease Prevention & Control and Animal Model, Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University (HUNAU), Changsha, Hunan 410128 China
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Deyong Duan;
Deyong Duan
1Lab of Animal Disease Prevention & Control and Animal Model, Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University (HUNAU), Changsha, Hunan 410128 China
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Xiaomin Yuan;
Xiaomin Yuan
1Lab of Animal Disease Prevention & Control and Animal Model, Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University (HUNAU), Changsha, Hunan 410128 China
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Lingchen Yang;
Lingchen Yang
1Lab of Animal Disease Prevention & Control and Animal Model, Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University (HUNAU), Changsha, Hunan 410128 China
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Aibing Wang
1Lab of Animal Disease Prevention & Control and Animal Model, Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University (HUNAU), Changsha, Hunan 410128 China
3PCB Biotechnology LLC, Rockville, Maryland 20852, U.S.A.
Correspondence: Aibing Wang (bingaiwang@hunau.edu.cn)
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Publisher: Portland Press Ltd
Received:
November 02 2021
Revision Received:
February 10 2022
Accepted:
February 15 2022
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2022
Biochem Soc Trans (2022) 50 (1): 597–607.
Article history
Received:
November 02 2021
Revision Received:
February 10 2022
Accepted:
February 15 2022
Citation
Jiayi He, Yixing Qiu, Lei Tan, Deyong Duan, Xiaomin Yuan, Lingchen Yang, Aibing Wang; Understanding the key functions of Myosins in viral infection. Biochem Soc Trans 28 February 2022; 50 (1): 597–607. doi: https://doi.org/10.1042/BST20211239
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