Mechanical forces, such as compression, shear stress and stretching, play major roles during development, tissue homeostasis and immune processes. These forces are translated into a wide panel of biological responses, ranging from changes in cell morphology, membrane transport, metabolism, energy production and gene expression. Recent studies demonstrate the role of autophagy in the integration of these physical constraints. Here we focus on the role of autophagy in the integration of shear stress induced by blood and urine flows in the circulatory system and the kidney, respectively. Many studies highlight the involvement of the primary cilium, a microtubule-based antenna present at the surface of many cell types, in the integration of extracellular stimuli. The cross-talk between the molecular machinery of autophagy and that of the primary cilium in the context of shear stress is revealed to be an important dialog in cell biology.
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December 2021
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Fuelled by the ‘resolution revolution’, cryo-EM has transformed our molecular understanding of transcriptional regulation in bacteria. As an example, Wood and colleagues (pp. 2695–2710) present the sialic acid gene repressor NanR (PDB-6WFG), where cryo-EM revealed the DNA-binding mode. “E. coli Bacteria” by NIAID is licensed under CC BY 2.0. Cover artwork courtesy of Christopher Horne.
Review Article|
November 08 2021
Primary cilium-dependent autophagy in the response to shear stress
In Collection
Cell death and survival
Etienne Morel;
Etienne Morel
Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université de Paris, Paris, France
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Nicolas Dupont;
Nicolas Dupont
Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université de Paris, Paris, France
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Patrice Codogno
Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université de Paris, Paris, France
Correspondence: Patrice Codogno (patrice.codogno@inserm.fr)
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Biochem Soc Trans (2021) 49 (6): 2831–2839.
Article history
Received:
August 28 2021
Revision Received:
October 14 2021
Accepted:
October 18 2021
Citation
Etienne Morel, Nicolas Dupont, Patrice Codogno; Primary cilium-dependent autophagy in the response to shear stress. Biochem Soc Trans 17 December 2021; 49 (6): 2831–2839. doi: https://doi.org/10.1042/BST20210810
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