MicroRNAs are short, non-coding RNAs that target messenger RNAs for degradation. miR-145 is a vascular-enriched microRNA that is important for smooth muscle cell (SMC) differentiation. Under healthy circumstances, SMC exist in a contractile, differentiated phenotype promoted by miR-145. In cases of disease or injury, SMC can undergo reversible dedifferentiation into a synthetic phenotype, accompanied by inhibition of miR-145 expression. Vascular disorders such as atherosclerosis and neointimal hyperplasia are characterised by aberrant phenotypic switching in SMC. This review will summarise the physiological roles of miR-145 in vascular SMC, including the molecular regulation of differentiation, proliferation and migration. Furthermore, it will discuss the different ways in which miR-145 can be dysregulated and the downstream impact this has on the progression of vascular pathologies. Finally, it will discuss whether miR-145 may be suitable for use as a biomarker of vascular disease.
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February 2021
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On the implications of the copper co-factor in lytic polysaccharide monooxygenase. A brief overview of structure, oxygen activation and application as bioindustrial process tools for decomposition of lignocellulose. Further information can be found in the review by Ipsen and colleagues (pages 531–540). Image provided by Katja Johansen.
Review Article|
February 22 2021
Diverse roles of microRNA-145 in regulating smooth muscle (dys)function in health and disease
Kirsten Riches-Suman
School of Chemistry and Biosciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, U.K.
Correspondence: Kirsten Riches-Suman (k.riches@bradford.ac.uk)
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Publisher: Portland Press Ltd
Received:
November 26 2020
Revision Received:
January 28 2021
Accepted:
January 29 2021
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2021
Biochem Soc Trans (2021) 49 (1): 353–363.
Article history
Received:
November 26 2020
Revision Received:
January 28 2021
Accepted:
January 29 2021
Citation
Kirsten Riches-Suman; Diverse roles of microRNA-145 in regulating smooth muscle (dys)function in health and disease. Biochem Soc Trans 26 February 2021; 49 (1): 353–363. doi: https://doi.org/10.1042/BST20200679
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