Bone plays critical roles in support, protection, movement, and metabolism. Although bone has an innate capacity for regeneration, this capacity is limited, and many bone injuries and diseases require intervention. Biomaterials are a critical component of many treatments to restore bone function and include non-resorbable implants to augment bone and resorbable materials to guide regeneration. Biomaterials can vary considerably in their biocompatibility and bioactivity, which are functions of specific material parameters. The success of biomaterials in bone augmentation and regeneration is based on their effects on the function of bone cells. Such functions include adhesion, migration, inflammation, proliferation, communication, differentiation, resorption, and vascularization. This review will focus on how different material parameters can enhance bone cell function both in vitro and in vivo.
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Review Article| September 17 2020
Review on material parameters to enhance bone cell function in vitro and in vivo
David H. Kohn
1Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, U.S.A.
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, U.S.A.
Correspondence: David H Kohn (email@example.com)
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Publisher: Portland Press Ltd
Received: June 25 2020
Revision Received: August 19 2020
Accepted: August 21 2020
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
Eric Madsen, Merjem Mededovic, David H. Kohn; Review on material parameters to enhance bone cell function in vitro and in vivo. Biochem Soc Trans 30 October 2020; 48 (5): 2039–2050. doi: https://doi.org/10.1042/BST20200210
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