In recent years, obesity has reached epidemic proportions globally and has become a major public health concern. The development of obesity is likely caused by several behavioral, environmental, and genetic factors. Genomic variability among individuals is largely due to copy number variations (CNVs). Recent genome-wide association studies (GWAS) have successfully identified many loci containing CNV related to obesity. These obesity-related CNVs are informative to the diagnosis and treatment of genomic diseases. A more comprehensive classification of CNVs may provide the basis for determining how genomic diversity impacts the mechanisms of expression for obesity in children and adults of a variety of genders and ethnicities. In this review, we summarize current knowledge on the relationship between obesity and the CNV of several genomic regions, with an emphasis on genes at the following loci: 11q11, 1p21.1, 10q11.22, 10q26.3, 16q12.2, 16p12.3, and 4q25.
-
Cover Image
Cover Image
The transcript is populated with numerous overlapping codes that regulate all steps of gene expression. These codes cannot be readily discovered and understood without the use of computational modelling and algorithms. In this issue (see pages 1519–1528), Bahiri-Elitzur and Tuller summarize and discuss the different approaches that have been employed in the field in recent years. This cover artwork has been created by Hagar Messer and was provided by Tamir Tuller.
DNA copy number and structural variation (CNV) contributions to adult and childhood obesity
Megan Phillips, Jeganathan Ramesh Babu, Xu Wang, Thangiah Geetha; DNA copy number and structural variation (CNV) contributions to adult and childhood obesity. Biochem Soc Trans 28 August 2020; 48 (4): 1819–1828. doi: https://doi.org/10.1042/BST20200556
Download citation file:
Sign in
Sign in to your personal account
Captcha Validation Error. Please try again.