The recruitment of the furanosidic scaffold of ribose as the crucial step for nucleotides and then for nucleic acids synthesis is presented. Based on the view that the selection of molecules to be used for relevant metabolic purposes must favor structurally well-defined molecules, the inadequacy of ribose as a preferential precursor for nucleotides synthesis is discussed. The low reliability of ribose in its furanosidic hemiacetal form must have played ab initio against the choice of d-ribose for the generation of d-ribose-5-phosphate, the fundamental precursor of the ribose moiety of nucleotides. The latter, which is instead generated through the ‘pentose phosphate pathway’ is strictly linked to the affordable and reliable pyranosidic structure of d-glucose.
The furanosidic scaffold of d-ribose: a milestone for cell life
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Antonella Del-Corso, Mario Cappiello, Roberta Moschini, Francesco Balestri, Umberto Mura, Piero Luigi Ipata; The furanosidic scaffold of d-ribose: a milestone for cell life. Biochem Soc Trans 20 December 2019; 47 (6): 1931–1940. doi: https://doi.org/10.1042/BST20190749
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