Myocardial Infarction (MI) initiates a series of wound healing events that begins with up-regulation of an inflammatory response and culminates in scar formation. The extracellular matrix (ECM) is intricately involved in all stages from initial break down of existing ECM to synthesis of new ECM to form the scar. This review will summarize our current knowledge on the processes involved in ECM remodeling after MI and identify the gaps that still need to be filled.

Keywords:
cardiovascular, extracellular matrix, fibroblasts, inflammation, macrophages, myocardial infarction
Subjects:
Cardiovascular System & Vascular Biology, Immunology & Inflammation, Molecular Interactions
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2019
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