The Escherichia coli lac operon promoter is widely used as a tool to control recombinant protein production in bacteria. Here, we give a brief review of how it functions, how it is regulated, and how, based on this knowledge, a suite of lac promoter derivatives has been developed to give a controlled expression that is suitable for diverse biotechnology applications.

Keywords:
bacterial transcription initiation, Escherichia coli, lac promoter, lac repressor, recombinant protein production, tac promoter
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2019
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