Various membrane trafficking pathways transport molecules through the endosomal system of eukaryotic cells, where trafficking decisions control the localisation and activity of a diverse repertoire of membrane protein cargoes. The budding yeast Saccharomyces cerevisiae has been used to discover and define many mechanisms that regulate conserved features of endosomal trafficking. Internalised surface membrane proteins first localise to endosomes before sorting to other compartments. Ubiquitination of endosomal membrane proteins is a signal for their degradation. Ubiquitinated cargoes are recognised by the endosomal sorting complex required for transport (ESCRT) apparatus, which mediate sorting through the multivesicular body pathway to the lysosome for degradation. Proteins that are not destined for degradation can be recycled to other intracellular compartments, such as the Golgi and the plasma membrane. In this review, we discuss recent developments elucidating the mechanisms that drive membrane protein degradation and recycling pathways in yeast.
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December 2018
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Dysfunctional cytoskeleton and neurodegeneration: novel pathways in Parkinson's disease? This image represents the degeneration of the neuronal tree during the aging process. In this issue Civiero et al. discuss the consequence of impaired cytoskeletal dynamics on neurite morphology and neuronal physiology in Parkinson's disease. For further details see pages 1653–1663.
Review Article|
October 31 2018
Endosomal trafficking of yeast membrane proteins
Kamilla M. E. Laidlaw;
Kamilla M. E. Laidlaw
1Biology Department, University of York, York YO10 5DD, U.K.
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Chris MacDonald
1Biology Department, University of York, York YO10 5DD, U.K.
Correspondence: Chris MacDonald (chris.macdonald@york.ac.uk)
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Publisher: Portland Press Ltd
Received:
July 19 2018
Revision Received:
September 01 2018
Accepted:
September 14 2018
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Biochem Soc Trans (2018) 46 (6): 1551–1558.
Article history
Received:
July 19 2018
Revision Received:
September 01 2018
Accepted:
September 14 2018
Citation
Kamilla M. E. Laidlaw, Chris MacDonald; Endosomal trafficking of yeast membrane proteins. Biochem Soc Trans 17 December 2018; 46 (6): 1551–1558. doi: https://doi.org/10.1042/BST20180258
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