Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may ‘trans-signal’ in a manner that is facilitated by its binding to a soluble derivative of the IL-6 receptor (sIL-6R). Resultant signal transduction is, respectively, driven by the association of IL-6/IL-6R or IL-6/sIL-6R complex with the membrane-associated signal transducer, gp130 (Glycoprotein 130). Distinct JAK (Janus tyrosine kinase)/STAT (signal transducers and activators of transcription) and other signalling pathways are activated as a consequence. Of translational relevance, overexpression of IL-6 has been documented in several neoplastic disorders, including but not limited to colorectal, ovarian and breast cancer and several haematological malignancies. This review attempts to summarise our current understanding of the role of IL-6 in cancer development. In short, these studies have shown important roles for IL-6 signalling in tumour cell growth and survival, angiogenesis, immunomodulation of the tumour microenvironment, stromal cell activation, and ultimate disease progression. Given this background, we also consider the potential for therapeutic targeting of this system in cancer.
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Review Article| November 22 2018
The role of the interleukin (IL)-6/IL-6 receptor axis in cancer
Mustafa Yassin Taher;
David Marc Davies;
1King's College London, School of Cancer and Pharmaceutical Studies, Guy's Hospital, Great Maze Pond, London SE1 9RT, U.K.
3Department of Clinical Immunology and Allergy, King's College Hospital NHS Foundation Trust, London, U.K.
4Department of Immunology, Eastbourne Hospital, East Sussex BN21 2UD, U.K.
Correspondence: John Maher (email@example.com)
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Mustafa Yassin Taher, David Marc Davies, John Maher; The role of the interleukin (IL)-6/IL-6 receptor axis in cancer. Biochem Soc Trans 17 December 2018; 46 (6): 1449–1462. doi: https://doi.org/10.1042/BST20180136
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