Post-translational modification (PTM) of histones has been investigated in eukaryotes for years, revealing its widespread occurrence and functional importance. Many PTMs affect chromatin folding and gene activity. Only recently the occurrence of such modifications has been recognized in bacteria. However, it is unclear whether PTM of the bacterial counterparts of eukaryotic histones, nucleoid-associated proteins (NAPs), bears a comparable significance. Here, we scrutinize proteome mass spectrometry data for PTMs of the four most abundantly present NAPs in Escherichia coli (H-NS, HU, IHF and FIS). This approach allowed us to identify a total of 101 unique PTMs in the 11 independent proteomic studies covered in this review. Combined with structural and genetic information on these proteins, we describe potential effects of these modifications (perturbed DNA-binding, structural integrity or interaction with other proteins) on their function.
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October 2018
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Cover Image
Cover Image
In this issue, Mahkoul et al. discuss the relationship between the architecture of the Golgi, the cytoskeleton and the regulation of signalling networks in the cytoplasm and nucleus. The cover image, provided by the authors, shows fluorescently labelled cells: actin (magenta), Golgi (red) late endosomes/lysosomes (green) and nucleus (blue). For further details see pages 1063–1072.
Review Article|
October 04 2018
Post-translational modification of nucleoid-associated proteins: an extra layer of functional modulation in bacteria?
Ivar W. Dilweg;
Ivar W. Dilweg
1Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
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Remus T. Dame
1Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
2Centre for Microbial Cell Biology, Leiden University, Leiden, The Netherlands
Correspondence: Remus T. Dame (rtdame@chem.leidenuniv.nl)
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Biochem Soc Trans (2018) 46 (5): 1381–1392.
Article history
Received:
July 16 2018
Revision Received:
August 31 2018
Accepted:
September 04 2018
Citation
Ivar W. Dilweg, Remus T. Dame; Post-translational modification of nucleoid-associated proteins: an extra layer of functional modulation in bacteria?. Biochem Soc Trans 19 October 2018; 46 (5): 1381–1392. doi: https://doi.org/10.1042/BST20180488
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