Embryogenesis requires an exquisite regulation of cell proliferation, cell cycle withdrawal and differentiation into a massively diverse range of cells at the correct time and place. Stem cells also remain to varying extents in different adult tissues, acting in tissue homeostasis and repair. Therefore, regulated proliferation and subsequent differentiation of stem and progenitor cells remains pivotal throughout life. Recent advances have characterised the cell cycle dynamics, epigenetics, transcriptome and proteome accompanying the transition from proliferation to differentiation, revealing multiple bidirectional interactions between the cell cycle machinery and factors driving differentiation. Here, we focus on a direct mechanistic link involving phosphorylation of differentiation-associated transcription factors by cell cycle-associated Cyclin-dependent kinases. We discuss examples from the three embryonic germ layers to illustrate this regulatory mechanism that co-ordinates the balance between cell proliferation and differentiation.
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October 2018
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Cover Image
Cover Image
In this issue, Mahkoul et al. discuss the relationship between the architecture of the Golgi, the cytoskeleton and the regulation of signalling networks in the cytoplasm and nucleus. The cover image, provided by the authors, shows fluorescently labelled cells: actin (magenta), Golgi (red) late endosomes/lysosomes (green) and nucleus (blue). For further details see pages 1063–1072.
Review Article|
September 21 2018
Cell cycle-dependent phosphorylation and regulation of cellular differentiation
Laura J.A. Hardwick;
Laura J.A. Hardwick
1Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, U.K.
2Peterhouse, Cambridge CB2 1RD, U.K.
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Roberta Azzarelli;
Roberta Azzarelli
1Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, U.K.
3Wellcome Trust/MRC Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, U.K.
4Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, U.K.
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Anna Philpott
1Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, U.K.
3Wellcome Trust/MRC Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, U.K.
Correspondence: Anna Philpott (ap113@cam.ac.uk)
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Biochem Soc Trans (2018) 46 (5): 1083–1091.
Article history
Received:
June 19 2018
Revision Received:
August 02 2018
Accepted:
August 03 2018
Citation
Laura J.A. Hardwick, Roberta Azzarelli, Anna Philpott; Cell cycle-dependent phosphorylation and regulation of cellular differentiation. Biochem Soc Trans 19 October 2018; 46 (5): 1083–1091. doi: https://doi.org/10.1042/BST20180276
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