Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here, we consider apoptotic cell-derived extracellular vesicles and the role of contained lipids and lipid mediators in ensuring effective control of inflammation. We discuss key outstanding issues in the study of cell death and cell communication, and introduce the concept of the ‘active extracellular vesicle’ as a metabolically active and potentially changing intercellular communicator.
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Review Article| May 09 2018
Communicating with the dead: lipids, lipid mediators and extracellular vesicles
1School of Life and Health Sciences, Aston University, Birmingham B4 7ET, U.K.
2Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, U.K.
Correspondence: Andrew Devitt (email@example.com)
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Helen R. Griffiths;
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Andrew Devitt, Helen R. Griffiths, Ivana Milic; Communicating with the dead: lipids, lipid mediators and extracellular vesicles. Biochem Soc Trans 19 June 2018; 46 (3): 631–639. doi: https://doi.org/10.1042/BST20160477
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