The degradation of plasma membrane and other membrane-associated proteins require their sorting at endosomes for delivery to the vacuole. Through the endocytic pathway, ubiquitinated membrane proteins (cargo) are delivered to endosomes where the ESCRT (endosomal sorting complex required for transport) machinery sorts them into intralumenal vesicles for degradation. Plants contain both conserved and plant-specific ESCRT subunits. In this review, I discuss the role of characterized plant ESCRT components, the evolutionary diversification of the plant ESCRT machinery, and a recent study showing that endosomal intralumenal vesicles form in clusters of concatenated vesicle buds by temporally uncoupling membrane constriction from membrane fission.
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Review Article| April 17 2018
ESCRT-mediated sorting and intralumenal vesicle concatenation in plants
Marisa S. Otegui
1Department of Botany, University of Wisconsin-Madison, 430 Lincoln Drive, Madison, WI 53706, U.S.A.
2R.M. Bock Laboratories of Cell and Molecular Biology, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, U.S.A.
3Department of Genetics, University of Wisconsin-Madison, 405 Henry Mall, Madison, WI 53706, U.S.A.
Correspondence: Marisa S. Otegui (firstname.lastname@example.org)
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Marisa S. Otegui; ESCRT-mediated sorting and intralumenal vesicle concatenation in plants. Biochem Soc Trans 19 June 2018; 46 (3): 537–545. doi: https://doi.org/10.1042/BST20170439
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