Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins including small Ubl modifier (SUMO) are small proteins which are covalently linked to target proteins to regulate their functions. In this review, we discuss the current state of the art and point out what we feel this field urgently needs in order to delineate the wiring of the system. We discuss what is needed to unravel the connections between different components of the conjugation machineries for ubiquitylation and SUMOylation, and to unravel the connections between the conjugation machineries and their substrates. Chemical probes are key tools to probe signal transduction by these small proteins that may help understand their action. This rapidly moving field has resulted in various small molecules that will help us to further understand Ub and SUMO function and that may lead to the development of new drugs.
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April 2018
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A 3D rendering of a Ubiquitin protein molecule. In this issue of Biochemical Society Transactions, Ovaa and Vertegaal discuss the role of ubiquitination and SUMO proteins in conjugation and deconjugation machineries; for details, see pages 423–436.
Review Article|
March 27 2018
Probing ubiquitin and SUMO conjugation and deconjugation
Huib Ovaa;
1Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
2Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Correspondence: Huib Ovaa (h.ovaa@lumc.nl) or Alfred C.O. Vertegaal (vertegaal@lumc.nl)
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Alfred C.O. Vertegaal
2Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Correspondence: Huib Ovaa (h.ovaa@lumc.nl) or Alfred C.O. Vertegaal (vertegaal@lumc.nl)
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Publisher: Portland Press Ltd
Received:
February 04 2018
Revision Received:
February 25 2018
Accepted:
February 28 2018
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Biochem Soc Trans (2018) 46 (2): 423–436.
Article history
Received:
February 04 2018
Revision Received:
February 25 2018
Accepted:
February 28 2018
Citation
Huib Ovaa, Alfred C.O. Vertegaal; Probing ubiquitin and SUMO conjugation and deconjugation. Biochem Soc Trans 17 April 2018; 46 (2): 423–436. doi: https://doi.org/10.1042/BST20170086
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