Here, we describe a recently discovered O-GlcNAc transferase termed EOGT for EGF domain-specific O-GlcNAc transferase. EOGT transfers GlcNAc (N-acetylglucosamine) to Ser or Thr in secreted and membrane proteins that contain one or more epidermal growth factor-like repeats with a specific consensus sequence. Thus, EOGT is distinct from OGT, the O-GlcNAc transferase, that transfers GlcNAc to Ser/Thr in proteins of the cytoplasm or nucleus. EOGT and OGT are in separate cellular compartments and have mostly distinct substrates, although both can act on cytoplasmic (OGT) and lumenal (EOGT) domains of transmembrane proteins. The present review will describe known substrates of EOGT and biological roles for EOGT in Drosophila and humans. Mutations in EOGT that give rise to Adams–Oliver Syndrome in humans will also be discussed.
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April 2017
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This artistic rendition shows an Atomic Force Microscopy tip probing the mechanics of an individual virus particle. The colour scale of the particle indicates the deformation and stress of the viral shell obtained with Finite Element Analysis. The applied force is monitored by focusing a laser beam at the end of the microcantilever. For more information please see study by Moreno-Madrid et al. in this issue, pages 499–511. Image provided by Pedro De Pablo.
Review Article|
April 13 2017
EOGT and O-GlcNAc on secreted and membrane proteins
Shweta Varshney;
Shweta Varshney
1Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, U.S.A.
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Pamela Stanley
1Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, U.S.A.
Correspondence: Pamela Stanley (pamela.stanley@einstein.yu.edu)
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Publisher: Portland Press Ltd
Received:
November 23 2016
Revision Received:
February 01 2017
Accepted:
February 06 2017
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem Soc Trans (2017) 45 (2): 401–408.
Article history
Received:
November 23 2016
Revision Received:
February 01 2017
Accepted:
February 06 2017
Citation
Shweta Varshney, Pamela Stanley; EOGT and O-GlcNAc on secreted and membrane proteins. Biochem Soc Trans 15 April 2017; 45 (2): 401–408. doi: https://doi.org/10.1042/BST20160165
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