Pseudokinases and pseudophosphatases possess the ability to bind substrates without catalyzing their modification, thereby providing a mechanism to recruit potential phosphotargets away from active enzymes. Since many of these pseudoenzymes possess other characteristics such as localization signals, separate catalytic sites, and protein–protein interaction domains, they have the capacity to influence signaling dynamics in local environments. In a similar manner, the targeting of signaling enzymes to subcellular locations by A-kinase-anchoring proteins (AKAPs) allows for precise and local control of second messenger signaling events. Here, we will discuss how pseudoenzymes form ‘pseudoscaffolds’ and compare and contrast this compartment-specific regulatory role with the signal organization properties of AKAPs. The mitochondria will be the focus of this review, as they are dynamic organelles that influence a broad range of cellular processes such as metabolism, ATP synthesis, and apoptosis.
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April 2017
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Cover Image
Cover Image
This artistic rendition shows an Atomic Force Microscopy tip probing the mechanics of an individual virus particle. The colour scale of the particle indicates the deformation and stress of the viral shell obtained with Finite Element Analysis. The applied force is monitored by focusing a laser beam at the end of the microcantilever. For more information please see study by Moreno-Madrid et al. in this issue, pages 499–511. Image provided by Pedro De Pablo.
Review Article|
April 13 2017
Pseudoscaffolds and anchoring proteins: the difference is in the details
Stacey Aggarwal-Howarth;
Stacey Aggarwal-Howarth
1Howard Hughes Medical Institute and Department of Pharmacology, University of Washington, Seattle, WA, U.S.A.
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John D. Scott
1Howard Hughes Medical Institute and Department of Pharmacology, University of Washington, Seattle, WA, U.S.A.
Correspondence: John D. Scott (scottjdw@u.washington.edu)
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Publisher: Portland Press Ltd
Received:
December 19 2016
Revision Received:
January 18 2017
Accepted:
January 20 2017
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem Soc Trans (2017) 45 (2): 371–379.
Article history
Received:
December 19 2016
Revision Received:
January 18 2017
Accepted:
January 20 2017
Citation
Stacey Aggarwal-Howarth, John D. Scott; Pseudoscaffolds and anchoring proteins: the difference is in the details. Biochem Soc Trans 15 April 2017; 45 (2): 371–379. doi: https://doi.org/10.1042/BST20160329
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