3′-5′-Cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signalling is activated by different extracellular stimuli and mediates many diverse processes within the same cell. It is now well established that in order to translate into the appropriate cellular function multiple extracellular inputs, which may act simultaneously on the same cell, the cAMP/PKA signalling pathway is compartmentalised. Multimolecular complexes are organised at specific subcellular sites to generate spatially confined signalosomes, which include effectors, modulators and targets of the pathway. In recent years, it has become evident that mitochondria represent sites of compartmentalised cAMP signalling. However, the exact location and the molecular composition of distinct mitochondria signalosomes and their function remain largely unknown. In this review, we focus on individual components of the cAMP/PKA signalling pathway at distinct mitochondria subdomains represented by the outer and inner mitochondrial membranes, the intermembrane space and the matrix, highlighting some of the questions that remain unanswered.
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February 2017
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Cover Image
The surface of the catalytic subunit of protein phosphatase PP1 (central 3D-structure) has many binding sites for regulatory proteins that are embedded in regulatory networks (coloured circles linked by lines). Please see pp. 89–99 for more information. Image provided by Mathieu Bollen.
Review Article|
February 15 2017
Components of the mitochondrial cAMP signalosome
Stefania Monterisi;
1Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K.
Correspondence: Stefania Monterisi (stefania.monterisi@dpag.ox.ac.uk)
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Manuela Zaccolo
1Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K.
Correspondence: Stefania Monterisi (stefania.monterisi@dpag.ox.ac.uk)
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Publisher: Portland Press Ltd
Received:
October 25 2016
Revision Received:
December 16 2016
Accepted:
December 21 2016
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem Soc Trans (2017) 45 (1): 269–274.
Article history
Received:
October 25 2016
Revision Received:
December 16 2016
Accepted:
December 21 2016
Citation
Stefania Monterisi, Manuela Zaccolo; Components of the mitochondrial cAMP signalosome. Biochem Soc Trans 8 February 2017; 45 (1): 269–274. doi: https://doi.org/10.1042/BST20160394
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