Chronic heart failure is a common consequence of various heart diseases. Mechanical force is known to play a key role in heart failure development through regulating cardiomyocyte hypertrophy. In order to understand the complex disease mechanism, this article discussed a multi-disciplinary approach that may aid the illustration of heart failure molecular process.

Keywords:
Drosophila melanogaster, heart failure, integrins, mechanical forces, mechanotransduction
Subjects:
Biophysics, Cardiovascular System & Vascular Biology, Translational Science
© 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2016
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