The bone morphogenetic protein (BMP) pathway is a major conserved signalling pathway with diverse roles in development and homeostasis. Given that cells exist in three-dimensional environments, one important area is to understand how the BMP pathway operates within such complex cellular environments. The extracellular matrix contains information regarding tissue architecture and its mechanical properties that is transmitted to the cell via integrin receptors. In this review, I describe various examples of modulation of the BMP pathway by integrins. In the case of the Drosophila embryo and some cell line-based studies, integrins have been found to enhance BMP responses through different mechanisms, such as enhancement of BMP ligand–receptor binding and effects on Smad phosphorylation or stability. In these contexts, BMP-dependent activation of integrins is a common theme. However, I also discuss examples where integrins inhibit the BMP pathway, highlighting the context-dependent nature of integrin–BMP cross-talk.
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October 2016
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Alternative splicing of intrinsically disordered segments can rewire protein interaction networks. In this issue, the Biochemical Society’s Colworth Medal winner, M. Madan Babu explores the contribution of intrinsically disordered regions to protein function, cellular complexity and human disease; see pages 1185–1200. [Credit: Guilhem Chalancon, MRC Laboratory of Molecular Biology, Cambridge, UK.]
Review Article|
October 19 2016
Modulation of BMP signalling by integrins
Hilary L. Ashe
Hilary L. Ashe
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
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Publisher: Portland Press Ltd
Received:
April 28 2016
Revision Received:
July 11 2016
Accepted:
July 15 2016
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2016
Biochem Soc Trans (2016) 44 (5): 1465–1473.
Article history
Received:
April 28 2016
Revision Received:
July 11 2016
Accepted:
July 15 2016
Citation
Hilary L. Ashe; Modulation of BMP signalling by integrins. Biochem Soc Trans 15 October 2016; 44 (5): 1465–1473. doi: https://doi.org/10.1042/BST20160111
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