Protein tyrosine phosphatases (PTPs) perform specific functions in vivo, despite being vastly outnumbered by their substrates. Because of this and due to the central roles PTPs play in regulating cellular function, PTP activity is regulated by a large variety of molecular mechanisms. We review evidence that indicates that the divergent C-terminal tail sequences (C-terminal domains, CTDs) of receptor-type PTPs (RPTPs) help regulate RPTP function by controlling intermolecular associations in a way that is itself subject to physiological regulation. We propose that the CTD of each RPTP defines an ‘interaction code’ that helps determine molecules it will interact with under various physiological conditions, thus helping to regulate and diversify PTP function.
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October 2016
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Alternative splicing of intrinsically disordered segments can rewire protein interaction networks. In this issue, the Biochemical Society’s Colworth Medal winner, M. Madan Babu explores the contribution of intrinsically disordered regions to protein function, cellular complexity and human disease; see pages 1185–1200. [Credit: Guilhem Chalancon, MRC Laboratory of Molecular Biology, Cambridge, UK.]
Review Article|
October 19 2016
Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains
Maayan Barnea;
Maayan Barnea
1Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
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Tsviya Olender;
Tsviya Olender
1Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
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Mark T. Bedford;
Mark T. Bedford
2Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center, University of Texas, Smithville, TX 78957, USA
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Ari Elson
Ari Elson
1Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
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Publisher: Portland Press Ltd
Received:
June 01 2016
Revision Received:
July 06 2016
Accepted:
July 11 2016
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2016
Biochem Soc Trans (2016) 44 (5): 1295–1303.
Article history
Received:
June 01 2016
Revision Received:
July 06 2016
Accepted:
July 11 2016
Citation
Maayan Barnea, Tsviya Olender, Mark T. Bedford, Ari Elson; Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains. Biochem Soc Trans 15 October 2016; 44 (5): 1295–1303. doi: https://doi.org/10.1042/BST20160141
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