Several recent studies have demonstrated the existence of membrane contact sites (MCS) between intracellular organelles in eukaryotic cells. Recent exciting studies have also demonstrated the existence of biomolecular interactions at these contact sites in mediating changes in the membrane composition of the cellular compartments. However, the role of such contact sites in regulating organelle function and physiological processes remains less clear. In this review we discuss the existence of a contact site between the plasma membrane (PM) and the endoplasmic reticulum (ER) in Drosophila photoreceptors. Further, we discuss the role of specific proteins present at this location in regulating phospholipid turnover and its impact in regulating a physiological process, namely phototransduction.
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April 2016
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Cover Image
Endoplasmic reticulumendosome contact sites. This pseudo-colored electron microscopy image shows the formation of inter-organelle membrane contact sites between late endosomes (magenta) and the endoplasmic reticulum (ER; green). This tethering results from the interaction between two ER-anchored proteins (VAP-A and VAP-B) and the late endosomeanchored protein STARD3NL. Mitochondria: brown; nucleus: blue. For further details see pp. 493-498. Image kindly provided by Fabien Alpy. - PDF Icon PDF LinkTable of Contents
Review Article|
April 11 2016
The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites
Shweta Yadav;
Shweta Yadav
*National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India
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Shamshad Cockcroft;
Shamshad Cockcroft
†Department of Neuroscience, Physiology and Pharmacology, University College, London WC1E 6JJ, U.K.
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Padinjat Raghu
Padinjat Raghu
1
*National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India
1To whom correspondence should be addressed (email praghu@ncbs.res.in).
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Publisher: Portland Press Ltd
Received:
January 25 2016
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2016 Authors; published by Portland Press Limited
2016
Biochem Soc Trans (2016) 44 (2): 447–451.
Article history
Received:
January 25 2016
Citation
Shweta Yadav, Shamshad Cockcroft, Padinjat Raghu; The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites. Biochem Soc Trans 15 April 2016; 44 (2): 447–451. doi: https://doi.org/10.1042/BST20150256
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