Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological calcium overload leads to the membrane depolarization and disruption of ATP production. mPTP activation has been implicated as a central event during the process of stress-induced cell death. mPTP is a supramolecular complex composed of many proteins. Recent studies suggest that mitochondrial ATPase plays the central role in the formation of mPTP. However, the structure of the central conducting pore part of mPTP (mPTPore) remains elusive. Here we review current models proposed for the mPTPore and involvement of polyP in its formation and regulation. We discuss the underestimated role of polyP as an effector and a putative structural component of the mPTPore. We propose the hypothesis that inclusion of polyP can explain such properties of mPTP activity as calcium activation, selectivity and voltage-dependence.
Skip Nav Destination
Article navigation
February 2016
-
Cover Image
Cover Image
Scanning electron micrograph of a cell from the endosperm of a barley grain. The cell is tightly packed with large, disk-shaped (A-type) and much smaller, almost spherical (B-type) starch granules. The smooth areas in this image are the surface of the cell walls of neighbouring endosperm cells. For further details see pp. 157-163. Image kindly provided by Elaine Barclay and Vasilios Andriotis (John Innes Centre, Norwich). - PDF Icon PDF LinkTable of Contents
Review Article|
February 09 2016
Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore
Maria E. Solesio;
Maria E. Solesio
*Department of Basic Sciences, New York University College of Dentistry, 345 East 24th Street, 10010, New York, NY, U.S.A.
Search for other works by this author on:
Pia A. Elustondo;
Pia A. Elustondo
†Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4R2
Search for other works by this author on:
Eleonora Zakharian;
Eleonora Zakharian
‡Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, 1 Illini Drive, 61605, Peoria, Il, U.S.A.
Search for other works by this author on:
Evgeny V. Pavlov
Evgeny V. Pavlov
*Department of Basic Sciences, New York University College of Dentistry, 345 East 24th Street, 10010, New York, NY, U.S.A.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
November 09 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2016 Authors; published by Portland Press Limited
2016
Biochem Soc Trans (2016) 44 (1): 7–12.
Article history
Received:
November 09 2015
Citation
Maria E. Solesio, Pia A. Elustondo, Eleonora Zakharian, Evgeny V. Pavlov; Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore. Biochem Soc Trans 15 February 2016; 44 (1): 7–12. doi: https://doi.org/10.1042/BST20150206
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.