Cytotoxic T-cells are crucial to protect us from intracellular pathogens and malignant cells. When T-cells become activated, they rapidly secrete cytokines, chemokines and cytotoxic granules that are critical to clear infected cells. However, when not properly regulated, these toxic effector molecules become one of the key mediators of autoimmune diseases. Therefore, a tight and multi-layered regulation of gene expression and protein production is required to ensure a protective yet balanced immune response. In this review, we describe how post-transcriptional events modulate the production of effector molecules in T-cells. In particular, we will focus on the role of cis-regulatory elements within the 3′-UTR of specific mRNAs and on RNA-binding proteins (RBPs) and non-coding RNAs that control the initiation and resolution of T-cell responses.
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December 2015
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Review Article|
November 27 2015
T-cells require post-transcriptional regulation for accurate immune responses
Fiamma Salerno;
Fiamma Salerno
*Sanquin Research Department of Hematopoiesis, and Landsteiner Laboratory, Academic Medical Centre (AMC), Experimental Immunology, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
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Monika C. Wolkers
Monika C. Wolkers
1
*Sanquin Research Department of Hematopoiesis, and Landsteiner Laboratory, Academic Medical Centre (AMC), Experimental Immunology, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
1To whom correspondence should be addressed (email m.wolkers@sanquin.nl).
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Publisher: Portland Press Ltd
Received:
July 10 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (6): 1201–1207.
Article history
Received:
July 10 2015
Citation
Fiamma Salerno, Monika C. Wolkers; T-cells require post-transcriptional regulation for accurate immune responses. Biochem Soc Trans 1 December 2015; 43 (6): 1201–1207. doi: https://doi.org/10.1042/BST20150154
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