ATP-binding cassette (ABC) transporters, belonging to the family D, are expressed in peroxisomes, endoplasmic reticulum or lysosomes. ABCD transporters play a role in transport of lipids, bile acids and vitamin B12 and associate with peroxisomal disorders. ABCD1 performs transport of coenzyme A esters of very-long-chain fatty acids (VLCFA) in peroxisomes and a number of mutations in ABCD1 gene were linked to an X-linked adrenoleucodystrophy (X-ALD). The role of ABCD transporters in tumour growth has not been studied in detail, but there is some evidence that ABCDs levels differ between undifferentiated stem or tumour cells and differentiated cells suggesting a possible link to tumorigenesis. In this mini-review, we discuss the available information about the role of ABCD transporters in cancer.
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October 2015
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Review Article|
October 09 2015
Role of family D ATP-binding cassette transporters (ABCD) in cancer
Viktor Hlaváč;
Viktor Hlaváč
1
*Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic
1To whom correspondence should be addressed (emailviktor.hlavac@szu.cz).
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Pavel Souček
Pavel Souček
*Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic
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Publisher: Portland Press Ltd
Received:
May 12 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (5): 937–942.
Article history
Received:
May 12 2015
Citation
Viktor Hlaváč, Pavel Souček; Role of family D ATP-binding cassette transporters (ABCD) in cancer. Biochem Soc Trans 1 October 2015; 43 (5): 937–942. doi: https://doi.org/10.1042/BST20150114
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