Tribbles (TRIB) proteins, a family of evolutionary conserved psuedokinase proteins, modulate various signalling pathways within the cell. The regulatory roles of TRIB make them an important part of a number of biological processes ranging from cell proliferation to metabolism, immunity, inflammation and carcinogenesis. Innate immune system plays a pivotal role during the regulation of reproductive processes that allows successful creation of an offspring. Its involvement initiates from fertilization of the oocyte by spermatozoon and lasts throughout early embryonic development, pregnancy and labour. Therefore, there is a close cooperation between the reproductive system and the innate immune system. Evidence from our lab has demonstrated that improper activation of the innate immune system can reduce embryo implantation, thus leading to infertility. Therefore, control mechanisms regulating the innate immune system function can be critical for successful reproductive events.
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October 2015
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Review Article|
October 09 2015
Tribbles role in reproduction
Shaghayegh Basatvat;
Shaghayegh Basatvat
*Academic Unit of Reproductive and Developmental Medicine, Department of Human Metabolism, The Medical School, University of Sheffield, Level 4, The Jessop Wing, Tree Root Walk, Sheffield S10 2SF, U.K.
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Deborah Angela Louise Carter;
Deborah Angela Louise Carter
†St James' Biomedical Services, University of Leeds, Clinical Sciences Building, St James' Hospital, Beckett Street, Leeds LS9 7TF, U.K.
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Endre Kiss-Toth;
Endre Kiss-Toth
‡Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, U.K.
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Alireza Fazeli
Alireza Fazeli
1
*Academic Unit of Reproductive and Developmental Medicine, Department of Human Metabolism, The Medical School, University of Sheffield, Level 4, The Jessop Wing, Tree Root Walk, Sheffield S10 2SF, U.K.
1To whom correspondence should be addressed (emaila.fazeli@sheffield.ac.uk).
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Publisher: Portland Press Ltd
Received:
May 15 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (5): 1116–1121.
Article history
Received:
May 15 2015
Citation
Shaghayegh Basatvat, Deborah Angela Louise Carter, Endre Kiss-Toth, Alireza Fazeli; Tribbles role in reproduction. Biochem Soc Trans 1 October 2015; 43 (5): 1116–1121. doi: https://doi.org/10.1042/BST20150121
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