The tribbles protein family, an evolutionarily conserved group of pseudokinases, have been shown to regulate multiple cellular events including those involved in normal and malignant haematopoiesis. The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ligase-binding domain. In this review, we focus on the role of Trib (mammalian Tribbles homologues) proteins in mammalian haematopoiesis and leukaemia. The Trib proteins show divergent expression in haematopoietic cells, probably indicating cell-specific functions. The roles of the Trib proteins in oncogenesis are also varied and appear to be tissue-specific. Finally, we discuss the potential mechanisms by which the Trib proteins preferentially regulate these processes in multiple cell types.
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October 2015
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Review Article|
October 09 2015
Tribbles in normal and malignant haematopoiesis
Sarah J. Stein;
Sarah J. Stein
*Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
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Ethan A. Mack;
Ethan A. Mack
*Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
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Kelly S. Rome;
Kelly S. Rome
*Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
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Warren S. Pear
Warren S. Pear
1
*Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
1To whom correspondence should be addressed (emailwpear@mail.med.upenn.edu).
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Publisher: Portland Press Ltd
Received:
May 13 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (5): 1112–1115.
Article history
Received:
May 13 2015
Citation
Sarah J. Stein, Ethan A. Mack, Kelly S. Rome, Warren S. Pear; Tribbles in normal and malignant haematopoiesis. Biochem Soc Trans 1 October 2015; 43 (5): 1112–1115. doi: https://doi.org/10.1042/BST20150117
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