The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction pathways. In the arthritides, inflammation and a wide variety of pro-inflammatory pathways have been implicated to drive the cartilage destruction and consequent disability associated with both rheumatoid arthritis (RA) and osteoarthritis (OA). Despite burgeoning evidence linking the TRIB to inflammation-related pathologies such as diabetes, multiple sclerosis and cancer, very little is known about their roles in arthritis. The present review discusses current knowledge of the impact of TRIB on pro-inflammatory cellular mechanisms and pathways known to be important in the pathogenesis of RA and OA.
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October 2015
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Review Article|
October 09 2015
Tribbles and arthritis: what are the links?
Andrew D. Rowan;
Andrew D. Rowan
1
*Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, U.K.
1To whom correspondence should be addressed (emaildrew.rowan@ncl.ac.uk).
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Gary J. Litherland
Gary J. Litherland
*Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, U.K.
†Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of the West of Scotland, Paisley Campus, Paisley PA1 2BE, Scotland
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Publisher: Portland Press Ltd
Received:
April 17 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
2015
Biochem Soc Trans (2015) 43 (5): 1051–1056.
Article history
Received:
April 17 2015
Citation
Andrew D. Rowan, Gary J. Litherland; Tribbles and arthritis: what are the links?. Biochem Soc Trans 1 October 2015; 43 (5): 1051–1056. doi: https://doi.org/10.1042/BST20150076
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