Platelet-derived SDF-1α (stromal cell derived factor-α) mediates inflammation, immune defence and repair mechanisms at site of tissue injury. This review summarizes the relative expression of CXC chemokine receptor 4 (CXCR4) and CXCR7 in platelets, their dynamic trafficking in presence of ligands like chemokine C-X-C-motif ligand 11 (CXCL11), CXCL12 and MIF (macrophage migration inhibitory factor); how these receptors differentially mediate the functional and survival response to the chemokines CXCL11, CXCL12 and MIF. We further elaborate and emphasize the prognostic significance of platelet surface expression of CXCR4–CXCR7 in the context of coronary artery disease (CAD). SDF-1α/CXCL12, CXCL11, MIF effects mediated through CXCR4 and CXCR7 may play a regulatory role at the site of vascular and tissue inflammation, immune defence and repair where activated platelets reach as forerunners and function as critical players.
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August 2015
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Review Article|
August 03 2015
Role of chemokine receptors CXCR4 and CXCR7 for platelet function
Madhumita Chatterjee;
Madhumita Chatterjee
1
*Innere Medizin III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universität, 72076 Tübingen, Germany
1To whom correspondence should be addressed (emailmeinrad.gawaz@med.uni-tuebingen.de).
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Dominik Rath;
Dominik Rath
*Innere Medizin III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universität, 72076 Tübingen, Germany
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Meinrad Gawaz
Meinrad Gawaz
1
*Innere Medizin III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universität, 72076 Tübingen, Germany
1To whom correspondence should be addressed (emailmeinrad.gawaz@med.uni-tuebingen.de).
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Biochem Soc Trans (2015) 43 (4): 720–726.
Article history
Received:
May 12 2015
Citation
Madhumita Chatterjee, Dominik Rath, Meinrad Gawaz; Role of chemokine receptors CXCR4 and CXCR7 for platelet function. Biochem Soc Trans 1 August 2015; 43 (4): 720–726. doi: https://doi.org/10.1042/BST20150113
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