The discovery that nuclear factor erythroid 2-related factor 2 (Nrf2) undergoes translocational oscillations from cytoplasm to nucleus in human cells with frequency modulation linked to activation of a stress-stimulated cytoprotective response raises the prospect that the Nrf2 works mechanistically analogous to a wireless sensor. Herein, we consider how this new model of Nrf2 oscillation resolves previous inexplicable experimental findings on Nrf2 regulation and why it is fit-for-purpose. Further investigation is required to assess how generally applicable the oscillatory mechanism is and if characteristics of this regulatory control can be found in vivo. It suggests there are multiple, potentially re-enforcing receptors for Nrf2 activation, indicating that potent Nrf2 activation for improved health and treatment of disease may be achieved through combination of Nrf2 system stimulants.
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August 2015
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Review Article|
August 03 2015
Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor
Mingzhan Xue;
Mingzhan Xue
*Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.
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Hiroshi Momiji;
Hiroshi Momiji
†Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry CV4 7AL, U.K.
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Naila Rabbani;
Naila Rabbani
*Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.
†Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry CV4 7AL, U.K.
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Till Bretschneider;
Till Bretschneider
†Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry CV4 7AL, U.K.
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David A. Rand;
David A. Rand
†Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry CV4 7AL, U.K.
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Paul J. Thornalley
Paul J. Thornalley
1
*Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.
†Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry CV4 7AL, U.K.
1To whom correspondence should be addressed (emailP.J.Thornalley@warwick.ac.uk).
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Biochem Soc Trans (2015) 43 (4): 669–673.
Article history
Received:
February 27 2015
Citation
Mingzhan Xue, Hiroshi Momiji, Naila Rabbani, Till Bretschneider, David A. Rand, Paul J. Thornalley; Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor. Biochem Soc Trans 1 August 2015; 43 (4): 669–673. doi: https://doi.org/10.1042/BST20150060
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