The mitochondrial 18-kDa translocator protein (TSPO) was originally discovered as a peripheral binding site of benzodiazepines to be later described as a core element of cholesterol trafficking between cytosol and mitochondria from which the current nomenclature originated. The high affinity it exhibits with chemicals (i.e. PK11195) has generated interest in the development of mitochondrial based TSPO-binding drugs for in vitro and in vivo analysis. Increased TSPO expression is observed in numerous pathologies such as cancer and inflammatory conditions of the central nervous system (CNS) that have been successfully exploited via protocols of positron emission tomography (PET) imaging. We endeavoured to dissect the molecular role of TSPO in mitochondrial cell biology and discovered a functional link with quality control mechanisms operated by selective autophagy. This review focuses on the current understanding of this pathway and focuses on the interplay with reactive oxygen species (ROS) and the voltage-dependent anion channel (VDAC), to which TSPO binds, in the regulation of cell mitophagy and hence homoeostasis of the mitochondrial network as a whole.
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Review Article| August 03 2015
TSPO is a REDOX regulator of cell mitophagy
Michelangelo Campanella 1
*Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London NW1 0TU, U.K.
†University College London Consortium for Mitochondrial Research, Royal College, London WC1 6BT, U.K.
1To whom correspondence should be addressed (firstname.lastname@example.org).
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Publisher: Portland Press Ltd
Received: February 05 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2015 Authors; published by Portland Press Limited
Jemma Gatliff, Michelangelo Campanella; TSPO is a REDOX regulator of cell mitophagy. Biochem Soc Trans 1 August 2015; 43 (4): 543–552. doi: https://doi.org/10.1042/BST20150037
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