PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP production, stress-response and mitochondrial dynamics and quality control. The orchestration of such a wide array of functions by an individual kinase requires a fine-tuned and versatile regulation of its activity. PINK1 proteolytic processing, trafficking and localization, as well as different post-translational modifications, affect its activity and function. Unravelling the regulatory mechanisms of PINK1 is essential for a full comprehension of its kinase function in health and disease.
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April 2015
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Conference Article|
April 07 2015
PINK1 activation–turning on a promiscuous kinase
Liesbeth Aerts;
Liesbeth Aerts
*Center for Human Genetics, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium
†VIB Center for the Biology of Disease, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium
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Bart De Strooper;
Bart De Strooper
1
*Center for Human Genetics, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium
‡University College London, Institute of Neurology, Queen Square, London WC1N 3BG, U.K.
1Correspondence may be addressed to either of these authors (emailVanessa.Morais@cme.vib-kuleuven.be or Bart.DeStrooper@cme.vib-kuleuven.be).
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Vanessa A. Morais
Vanessa A. Morais
1
*Center for Human Genetics, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium
†VIB Center for the Biology of Disease, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium
1Correspondence may be addressed to either of these authors (emailVanessa.Morais@cme.vib-kuleuven.be or Bart.DeStrooper@cme.vib-kuleuven.be).
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Publisher: Portland Press Ltd
Received:
January 06 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (2): 280–286.
Article history
Received:
January 06 2015
Citation
Liesbeth Aerts, Bart De Strooper, Vanessa A. Morais; PINK1 activation–turning on a promiscuous kinase. Biochem Soc Trans 1 April 2015; 43 (2): 280–286. doi: https://doi.org/10.1042/BST20150002
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