In 1995, in the Biochemical Society Transactions, Mundy published the first review on CLIMP-63 (cytoskeleton-linking membrane protein 63) or CKPA4 (cytoskeleton-associated protein 4), initially just p63 [1]. Here we review the following 20 years of research on this still mysterious protein. CLIMP-63 is a type II transmembrane protein, the cytosolic domain of which has the capacity to bind microtubules whereas the luminal domain can form homo-oligomeric complexes, not only with neighbouring molecules but also, in trans, with CLIMP-63 molecules on the other side of the endoplasmic reticulum (ER) lumen, thus promoting the formation of ER sheets. CLIMP-63 however also appears to have a life at the cell surface where it acts as a ligand-activated receptor. The still rudimentary information of how CLIMP-63 fulfills these different roles, what these are exactly and how post-translational modifications control them, will be discussed.
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April 2015
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Conference Article|
April 07 2015
How many lives does CLIMP-63 have?
Patrick A. Sandoz;
Patrick A. Sandoz
*Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Station 19, 1015 Lausanne, Switzerland
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F. Gisou van der Goot
F. Gisou van der Goot
1
*Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Station 19, 1015 Lausanne, Switzerland
1To whom correspondence should be addressed (emailgisou.vandergoot@epfl.ch).
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Publisher: Portland Press Ltd
Received:
December 12 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (2): 222–228.
Article history
Received:
December 12 2014
Citation
Patrick A. Sandoz, F. Gisou van der Goot; How many lives does CLIMP-63 have?. Biochem Soc Trans 1 April 2015; 43 (2): 222–228. doi: https://doi.org/10.1042/BST20140272
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