Precise regulation of protein assembly at specialized membrane domains is essential for diverse cellular functions including synaptic transmission. However, it is incompletely understood how protein clustering at the plasma membrane is initiated, maintained and controlled. Protein palmitoylation, a common post-translational modification, regulates protein targeting to the plasma membrane. Such modified proteins are enriched in these specialized membrane domains. In this review, we focus on palmitoylation of PSD-95, which is a major postsynaptic scaffolding protein and makes discrete postsynaptic nanodomains in a palmitoylation-dependent manner and discuss a determinant role of local palmitoylation cycles in creating highly localized hotspots at the membrane where specific proteins concentrate to organize functional domains.
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April 2015
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Conference Article|
April 07 2015
Postsynaptic nanodomains generated by local palmitoylation cycles
Masaki Fukata;
Masaki Fukata
1
*Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; and Department of Physiological Sciences, School of Life Science, SOKENDAI (the Graduate University for Advanced Studies), Okazaki 444-8787, Japan
1To whom correspondence should be addressed (emailmfukata@nips.ac.jp).
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Atsushi Sekiya;
Atsushi Sekiya
*Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; and Department of Physiological Sciences, School of Life Science, SOKENDAI (the Graduate University for Advanced Studies), Okazaki 444-8787, Japan
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Tatsuro Murakami;
Tatsuro Murakami
*Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; and Department of Physiological Sciences, School of Life Science, SOKENDAI (the Graduate University for Advanced Studies), Okazaki 444-8787, Japan
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Norihiko Yokoi;
Norihiko Yokoi
*Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; and Department of Physiological Sciences, School of Life Science, SOKENDAI (the Graduate University for Advanced Studies), Okazaki 444-8787, Japan
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Yuko Fukata
Yuko Fukata
*Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; and Department of Physiological Sciences, School of Life Science, SOKENDAI (the Graduate University for Advanced Studies), Okazaki 444-8787, Japan
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Publisher: Portland Press Ltd
Received:
January 14 2015
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (2): 199–204.
Article history
Received:
January 14 2015
Citation
Masaki Fukata, Atsushi Sekiya, Tatsuro Murakami, Norihiko Yokoi, Yuko Fukata; Postsynaptic nanodomains generated by local palmitoylation cycles. Biochem Soc Trans 1 April 2015; 43 (2): 199–204. doi: https://doi.org/10.1042/BST20140238
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